Eric Lawitz Selected Research

vaniprevir

6/2014	Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.
9/2013	Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.
7/2013	A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment.

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Eric Lawitz Research Topics

Disease

76	Infections 01/2023 - 11/2007
48	Fibrosis (Cirrhosis) 01/2024 - 08/2012
39	Chronic Hepatitis C 01/2019 - 11/2007
17	Hepatitis C 06/2019 - 08/2008
12	Fatigue 05/2019 - 04/2013
11	Anemia 01/2017 - 10/2010
10	Alcoholic Fatty Liver 11/2023 - 10/2018
10	Non-alcoholic Fatty Liver Disease 10/2023 - 01/2018
9	Nausea 11/2023 - 04/2013
8	Liver Diseases (Liver Disease) 01/2021 - 02/2014
7	Headache (Headaches) 05/2019 - 04/2012
6	Diarrhea 11/2023 - 04/2012
5	Pruritus (Itching) 11/2023 - 08/2008
5	Chronic Renal Insufficiency 01/2022 - 06/2016
5	Virus Diseases (Viral Diseases) 01/2018 - 08/2012
4	Inflammation (Inflammations) 10/2023 - 08/2012
4	Liver Cirrhosis (Hepatic Cirrhosis) 09/2023 - 01/2018
4	Persistent Infection 01/2015 - 11/2007
4	Neutropenia 06/2013 - 06/2011
3	Portal Hypertension 12/2023 - 01/2020
3	Body Weight (Weight, Body) 10/2023 - 01/2014
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 07/2014
3	Sleep Initiation and Maintenance Disorders (Insomnia) 05/2019 - 05/2013
2	Vomiting 11/2023 - 06/2014
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 11/2023 - 01/2019
2	Weight Loss (Weight Reduction) 10/2023 - 01/2023
2	Mental Disorders (Mental Disorder) 01/2021 - 02/2014
2	Chronic Disease (Chronic Diseases) 08/2014 - 06/2014
2	Exanthema (Rash) 07/2013 - 08/2008
1	Cholestasis 11/2023
1	Abdominal Pain (Pain, Abdominal) 11/2023
1	Hepatocellular Carcinoma (Hepatoma) 01/2023

Drug/Important Bio-Agent (IBA)

63	Ribavirin (Virazole)FDA LinkGeneric 01/2023 - 08/2008
33	SofosbuvirIBA 01/2023 - 01/2013
29	Antiviral Agents (Antivirals)IBA 01/2021 - 11/2007
28	InterferonsIBA 01/2019 - 12/2009
22	Protease Inhibitors (Protease Inhibitor)IBA 01/2018 - 04/2012
13	NucleotidesIBA 01/2019 - 03/2013
9	RNA (Ribonucleic Acid)IBA 01/2023 - 12/2011
9	daclatasvirIBA 06/2020 - 12/2011
8	paritaprevirIBA 05/2019 - 01/2013
8	peginterferon alfa-2a (Pegasys)FDA Link 02/2015 - 08/2008
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2018
7	ledipasvirIBA 10/2020 - 02/2014
7	Ritonavir (Norvir)FDA Link 05/2019 - 01/2013
7	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 09/2015 - 03/2011
6	velpatasvirIBA 01/2023 - 12/2015
6	SimeprevirIBA 06/2020 - 06/2014
6	ombitasvirIBA 05/2019 - 01/2014
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2014
6	grazoprevirIBA 11/2017 - 03/2015
5	glecaprevir and pibrentasvirIBA 01/2021 - 10/2017
5	dasabuvirIBA 05/2019 - 01/2013
5	elbasvirIBA 01/2017 - 03/2015
5	sofosbuvir drug combination ledipasvirIBA 01/2017 - 02/2014
5	telaprevirIBA 09/2015 - 08/2008
4	8- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamideIBA 02/2016 - 02/2014
4	asunaprevirIBA 02/2016 - 04/2012
3	Alanine Transaminase (SGPT)IBA 10/2019 - 08/2012
3	uprifosbuvirIBA 01/2019 - 11/2017
3	ruzasvirIBA 01/2019 - 11/2017
3	TabletsIBA 01/2017 - 04/2014
3	Erythropoietin FDA Link 06/2016 - 03/2011
3	vaniprevirIBA 06/2014 - 07/2013
2	obeticholic acidIBA 01/2024 - 12/2019
2	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2023 - 01/2023
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2023 - 02/2020
2	semaglutideIBA 10/2023 - 01/2023
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2020 - 10/2019
2	Triglycerides (Triacylglycerol)IBA 02/2020 - 10/2019
2	Drug CombinationsIBA 01/2019 - 01/2011
2	selonsertibIBA 10/2018 - 01/2018
2	simtuzumabIBA 10/2018 - 01/2018
2	CollagenIBA 01/2018 - 01/2018
2	glecaprevirIBA 01/2018 - 10/2017
2	wisteria lectinIBA 01/2018 - 01/2018
2	pibrentasvirIBA 01/2018 - 10/2017
2	sofosbuvir velpatasvir voxilaprevir drug combinationIBA 01/2017 - 01/2017
2	voxilaprevirIBA 01/2017 - 11/2016
2	GS-9451IBA 01/2016 - 07/2014
2	NucleosidesIBA 07/2014 - 02/2014
2	peginterferon alfa-2b (Pegintron)FDA Link 01/2013 - 01/2010
1	saroglitazarIBA 12/2023
1	2- (2,6- dimethyl- 4- (3- (4- (methylthio)phenyl)- 3- oxo- 1- propenyl)phenoxyl)- 2- methylpropanoic acidIBA 11/2023
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 11/2023
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2023
1	Alkaline PhosphataseIBA 11/2023
1	Amine Oxidase (Copper-Containing)IBA 11/2023
1	Glucagon-Like Peptide-1 ReceptorIBA 10/2023
1	Glucagon Receptors (Glucagon Receptor)IBA 10/2023
1	aldaferminIBA 09/2023
1	Hormones (Hormone)IBA 09/2023
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023

Therapy/Procedure

32	Therapeutics 10/2023 - 03/2011
6	Duration of Therapy 01/2021 - 02/2015
4	Aftercare (After-Treatment) 10/2018 - 04/2014
3	Liver Transplantation 05/2019 - 01/2017
3	Retreatment 01/2017 - 03/2011
2	Contraindications 11/2015 - 02/2014
2	Drug Tapering 11/2013 - 10/2010